{"title":"Eye \u0026 Lip","description":"The skin around the eye and on the lip is thinner and moves more than the rest of the face, so it is formulated for separately. These are lighter textures at gentler active levels, designed to be worn under or alongside the rest of a routine.","products":[{"product_id":"brightening-eye-cream","title":"PERIORBITAL COMFORT EYE CONCENTRATE","description":"\u003ch3\u003eThe Formula\u003c\/h3\u003e\n\u003cp\u003eThe Opuliss Skin Periorbital Comfort Eye Concentrate is a 15 ml \/ 0.51 fl oz periorbital concentrate built on a five-active stack: Aesculus Hippocastanum (Horse Chestnut) Seed Extract (Escin), Vitis Vinifera (Grape) Leaf Extract, Ginkgo Biloba Leaf Extract, Multi-Weight Hyaluronic Acid (Hydrolyzed Hyaluronic Acid plus Sodium Hyaluronate), and Oryza Sativa (Rice) Bran Oil. 100% natural origin, 10% organic origin, vegan eligible.\u003c\/p\u003e\n\u003ch3\u003eHow It Works\u003c\/h3\u003e\n\u003cp\u003e\u003cem\u003eFormulated for Dry Skin.\u003c\/em\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eEscin, a triterpene saponin from horse chestnut seed, the documented active behind the concentrate's periorbital comfort profile\u003csup\u003e1\u003c\/sup\u003e.\u003c\/li\u003e\n\u003cli\u003eMulti-Weight Hyaluronic Acid (Hydrolyzed Hyaluronic Acid plus Sodium Hyaluronate) hydrates the delicate under-eye area and helps the skin surface feel plumper and more comfortable\u003csup\u003e2\u003c\/sup\u003e.\u003c\/li\u003e\n\u003cli\u003eVitis Vinifera (Grape) Leaf Extract, a polyphenol antioxidant, helps defend the look of periorbital skin against environmental stress\u003csup\u003e3\u003c\/sup\u003e.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003csmall\u003eHero mechanism: escin, a triterpene saponin from horse chestnut seed, is the documented active behind under-eye comfort. Full mechanism and citations under Details and references.\u003c\/small\u003e\u003c\/p\u003e\n\u003ch3\u003eIngredients\u003c\/h3\u003e\n\u003cp\u003eAesculus Hippocastanum (Horse Chestnut) Seed Extract (Escin), Vitis Vinifera (Grape) Leaf Extract, Ginkgo Biloba Leaf Extract, Multi-Weight Hydrolyzed Hyaluronic Acid plus Sodium Hyaluronate, Oryza Sativa (Rice) Bran Oil.\u003c\/p\u003e\n\u003cp\u003eActive ingredients: Escin from Horse Chestnut, a triterpene saponin; Vitis Vinifera (Grape) Leaf Extract, a polyphenol antioxidant; Ginkgo Biloba Leaf Extract, a flavonoid antioxidant.\u003c\/p\u003e\n\u003ch3\u003eHow to Use\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eDispense one rice-grain quantity onto the ring finger.\u003c\/li\u003e\n\u003cli\u003ePat gently along the orbital bone from the inner corner outward, morning and evening after cleansing.\u003c\/li\u003e\n\u003cli\u003eAllow 30 seconds to absorb before layering serum or SPF. For external use only. Avoid direct contact with the eye surface.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSafety\u003c\/h3\u003e\n\u003cp\u003e100% natural origin, 10% organic origin, vegan eligible. Contains Parfum and naturally occurring fragrance allergens (Limonene, Geraniol, Coumarin, Linalool), including Coumarin, which is subject to enhanced allergen labelling. Patch test on the inner forearm for 24 hours before periorbital application, especially for those with known fragrance sensitivity. Avoid direct contact with the eye surface.\u003c\/p\u003e\n\u003ch3\u003eReferences\u003c\/h3\u003e\n\u003cp\u003eEscin, the active component of horse chestnut, is documented for reducing vascular permeability and for anti-edematous properties\u003csup\u003e1\u003c\/sup\u003e. Multi-Weight Hyaluronic Acid pairs surface-conditioning and penetrating molecular weights for periorbital humectant support\u003csup\u003e2\u003c\/sup\u003e. Vitis Vinifera (Grape) Leaf Extract contributes polyphenol antioxidant support\u003csup\u003e3\u003c\/sup\u003e, and Ginkgo Biloba Leaf Extract, a flavonoid botanical, contributes antioxidant cosmeceutical support\u003csup\u003e4\u003c\/sup\u003e.\u003c\/p\u003e\n\u003col class=\"op-refs\"\u003e\n\u003cli\u003eGallelli L. Escin: a review of its anti-edematous, anti-inflammatory, and venotonic properties. Drug Design, Development and Therapy. 2019;13:3425-3437. DOI 10.2147\/DDDT.S207720. PubMed PMID 31631970.\u003c\/li\u003e\n\u003cli\u003ePavicic T, Gauglitz GG, Lersch P, et al. Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. Journal of Drugs in Dermatology. 2011;10(9):990-1000. PubMed PMID 22052267.\u003c\/li\u003e\n\u003cli\u003eSangiovanni E, Di Lorenzo C, Piazza S, et al. Vitis vinifera L. Leaf Extract Inhibits In Vitro Mediators of Inflammation and Oxidative Stress Involved in Inflammatory-Based Skin Diseases. Antioxidants. 2019;8(5):134. DOI 10.3390\/antiox8050134. PubMed PMID 31100904.\u003c\/li\u003e\n\u003cli\u003eAbdellatif AAH, Mohammed HA, Al-Khalaf AM, et al. Ginkgo biloba leaves extract's cosmeceutical evaluation. Drug Development and Industrial Pharmacy. 2023;49(3):1-12. DOI 10.1080\/03639045.2023.2204374. PubMed PMID 37074796.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"op-cite\"\u003eHow to cite this product page: Opuliss. Periorbital Comfort Eye Concentrate. Opuliss Skin product page. 2026. https:\/\/opuliss.com\/products\/brightening-eye-cream\u003c\/p\u003e","brand":"Opuliss Beauty","offers":[{"title":"Default","offer_id":52244722974994,"sku":"192996","price":84.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/9195\/5986\/files\/brightening-eye-cream-square.jpg?v=1789186999"},{"product_id":"calming-eye-cream","title":"CANNABIDIOL EYE CREAM","description":"\u003ch3\u003eThe Formula\u003c\/h3\u003e\u003cp\u003eThe Opuliss Skin Cannabidiol Eye Cream is a 15 ml \/ 0.51 fl oz periorbital cream built on 1% Cannabidiol (CBD) in a Cannabis Sativa (Hemp) Seed Oil base, with horse chestnut escin, grape leaf, ginkgo biloba, multi-weight hyaluronic acid, and wild mango kernel butter. Formulated with EU-compliant cannabidiol (under 0.001% THC). 99% natural origin, 18% organic origin, vegan eligible.\u003c\/p\u003e\u003ch3\u003eHow It Works\u003c\/h3\u003e\u003cp\u003e\u003cem\u003eFormulated for Dry Skin, Redness and Rosacea, and Sensitive Skin.\u003c\/em\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eCannabidiol (CBD) at 1%, a phytocannabinoid that supports skin calming and comfort through the cutaneous endocannabinoid system.\u003c\/li\u003e\n\u003cli\u003eEscin, a vasoactive saponin from horse chestnut seed, studied for its effect on vascular permeability\u003csup\u003e1\u003c\/sup\u003e.\u003c\/li\u003e\n\u003cli\u003eMulti-weight hyaluronic acid, a humectant that hydrates at multiple depths of the stratum corneum\u003csup\u003e2\u003c\/sup\u003e.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003csmall\u003eHero mechanism: cannabidiol, a phytocannabinoid, interacts with the skin's endocannabinoid system to support calming and comfort. Full mechanism and citations under Details and references.\u003c\/small\u003e\u003c\/p\u003e\u003ch3\u003eIngredients\u003c\/h3\u003e\u003cp\u003eCannabis Sativa Hemp Seed Oil + Cannabidiol (CBD), Irvingia Gabonensis (Wild Mango) Kernel Butter, Aesculus Hippocastanum (Horse Chestnut) Seed Extract (Escin), Multi-Weight Hydrolyzed Hyaluronic Acid + Sodium Hyaluronate, Vitis Vinifera (Grape) Leaf Extract, Ginkgo Biloba Leaf Extract.\u003c\/p\u003e\u003cp\u003eActive ingredients: Cannabidiol (CBD) at 1%, a phytocannabinoid with a skin-calming role; Escin from horse chestnut, a triterpene saponin with a vasoactive supporting role; Ginkgo Biloba Leaf Extract, an antioxidant flavonoid. The formula is rounded out by Vitamin E (Tocopherol) and Vitamin C (Ascorbyl Palmitate) as an antioxidant supporting cast.\u003c\/p\u003e\u003ch3\u003eHow to Use\u003c\/h3\u003e\u003cul\u003e\n\u003cli\u003eDispense one rice-grain amount onto the ring finger.\u003c\/li\u003e\n\u003cli\u003ePat gently along the orbital bone from the inner corner outward. Do not pull the skin.\u003c\/li\u003e\n\u003cli\u003eUse morning and evening after cleansing, before moisturiser or SPF. Allow 30 seconds to absorb.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch3\u003eSafety\u003c\/h3\u003e\u003cp\u003e99% natural origin, 18% organic origin, vegan eligible. The cannabidiol is EU-compliant at under 0.001% THC. Contains naturally derived fragrance allergens (Limonene, Linalool, Geraniol, Citral). Patch test on the inner forearm for 24 hours before use. For external use only. Avoid direct eye contact. Not recommended during pregnancy or nursing without dermatologist consultation.\u003c\/p\u003e\u003ch3\u003eReferences\u003c\/h3\u003e\u003cp\u003eEscin, the vasoactive saponin in horse chestnut seed, has been studied for its effect on vascular permeability\u003csup\u003e1\u003c\/sup\u003e, while multi-weight hyaluronic acid hydrates at multiple depths of the stratum corneum\u003csup\u003e2\u003c\/sup\u003e. Ginkgo biloba leaf extract adds an antioxidant supporting role\u003csup\u003e3\u003c\/sup\u003e, and grape leaf extract contributes a venotonic supporting role\u003csup\u003e4\u003c\/sup\u003e. The hemp seed oil and wild mango kernel butter emollient base delivers balanced omega-6 and omega-3 essential fatty acids for cosmetic comfort and barrier feel, and plant-derived fatty acid oils of this kind are classified by the US Cosmetic Ingredient Review as skin-conditioning and emollient\u003csup\u003e5\u003c\/sup\u003e, complementing the 1% cannabidiol that anchors the formula.\u003c\/p\u003e\u003col class=\"op-refs\"\u003e\n\u003cli\u003eGallelli L. Drug Design, Development and Therapy. 2019;13:3425-3437. DOI 10.2147\/DDDT.S207720. PubMed PMID 31631970.\u003c\/li\u003e\n\u003cli\u003eNi C, Zhang Z, Wang Y, Zhang Z, Guo X, Lv H. Hyaluronic acid and HA-modified cationic liposomes for promoting skin penetration and retention. Journal of Controlled Release. 2023;357:432-443. DOI 10.1016\/j.jconrel.2023.03.049. PubMed PMID 37004799.\u003c\/li\u003e\n\u003cli\u003eAbdellatif AAH, Mohammed HA, Al-Khalaf AM, et al. Drug Development and Industrial Pharmacy. 2023;49(3):1-12. DOI 10.1080\/03639045.2023.2204374. PubMed PMID 37074796.\u003c\/li\u003e\n\u003cli\u003eReuter J, Wolfle U, Korting HC, Schempp C. Which plant for which skin disease? Part 2: Dermatophytes, chronic venous insufficiency, photoprotection, actinic keratoses, vitiligo, hair loss, cosmetic indications. Journal der Deutschen Dermatologischen Gesellschaft. 2010;8(11):866-873. DOI 10.1111\/j.1610-0387.2010.07472.x. PubMed PMID 20707877.\u003c\/li\u003e\n\u003cli\u003eBurnett CL, Fiume MM, Bergfeld WF, Belsito DV, et al. Safety Assessment of Plant-Derived Fatty Acid Oils. International Journal of Toxicology. 2017;36(3 suppl):51S-129S. DOI 10.1177\/1091581817740569. PubMed PMID 29243540.\u003c\/li\u003e\n\u003c\/ol\u003e\u003cp class=\"op-cite\"\u003eHow to cite this product page: Opuliss. Cannabidiol Eye Cream. Opuliss Skin product page. 2026. https:\/\/opuliss.com\/products\/calming-eye-cream\u003c\/p\u003e","brand":"Opuliss Beauty","offers":[{"title":"Default","offer_id":52244725268754,"sku":"193000","price":84.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/9195\/5986\/files\/calming-eye-cream-square.jpg?v=1789187025"},{"product_id":"smoothing-eye-cream","title":"BARRIER EYE CREAM","description":"\u003ch3\u003eThe Formula\u003c\/h3\u003e\n\u003cp\u003eA 15 ml \/ 0.51 fl oz periorbital eye cream composed around Dipalmitoyl Hydroxyproline (a collagen amino acid ester), Horse Chestnut Seed Extract standardised to escin, a Natural Ceramide Complex of Glycosphingolipids and Glycolipids, Black Tea Leaf Extract, and Multi-Weight Hyaluronic Acid. 100% natural origin, 18% organic origin, vegan eligible.\u003c\/p\u003e\n\u003ch3\u003eHow It Works\u003c\/h3\u003e\n\u003cp\u003e\u003cem\u003eFormulated for Dry Skin and Sensitive Skin.\u003c\/em\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eDipalmitoyl Hydroxyproline, a collagen amino acid ester, is a lipophilic carrier for hydroxyproline that conditions the appearance of thinner periorbital skin.\u003c\/li\u003e\n\u003cli\u003eEscin from Horse Chestnut Seed Extract, a venotonic botanical saponin, supports the appearance of a comforted, less puffy under-eye area\u003csup\u003e1\u003c\/sup\u003e.\u003c\/li\u003e\n\u003cli\u003eGlycosphingolipids and Glycolipids, a Natural Ceramide Complex, are barrier lipids that support the look of a supple, conditioned barrier.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003csmall\u003eHero mechanism: Dipalmitoyl Hydroxyproline, a collagen amino acid ester, is a lipophilic carrier that delivers hydroxyproline across the skin surface. Full mechanism and citations under Details and references.\u003c\/small\u003e\u003c\/p\u003e\n\u003ch3\u003eIngredients\u003c\/h3\u003e\n\u003cp\u003eDipalmitoyl Hydroxyproline (Collagen Amino Acid Ester), Escin + Aesculus Hippocastanum (Horse Chestnut) Seed Extract, Glycosphingolipids + Glycolipids (Natural Ceramide Complex), Camellia Sinensis (Black Tea) Leaf Extract, Multi-Weight Hydrolyzed Hyaluronic Acid + Sodium Hyaluronate.\u003c\/p\u003e\n\u003cp\u003eActive ingredients: Dipalmitoyl Hydroxyproline (a collagen amino acid ester); Escin from Horse Chestnut (a venotonic botanical saponin); Glycosphingolipids and Glycolipids (a Natural Ceramide Complex).\u003c\/p\u003e\n\u003ch3\u003eHow to Use\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eDispense a rice-grain quantity onto the ring finger and pat gently along the orbital bone from the inner corner outward.\u003c\/li\u003e\n\u003cli\u003eUse morning and evening after cleansing, before moisturiser or SPF. Allow 30 seconds to absorb.\u003c\/li\u003e\n\u003cli\u003eAvoid direct contact with the eye surface.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSafety\u003c\/h3\u003e\n\u003cp\u003e100% natural origin, 18% organic origin, vegan eligible. Contains naturally occurring fragrance allergens (Limonene, Linalool, Coumarin, Geraniol). Patch test on the inner forearm for 24 hours before periorbital application, especially with known fragrance sensitivity. Avoid direct contact with the eye surface.\u003c\/p\u003e\n\u003ch3\u003eReferences\u003c\/h3\u003e\n\u003cp\u003eEscin, a triterpene saponin from Aesculus Hippocastanum (Horse Chestnut) seed, is documented for venotonic and anti-edematous properties\u003csup\u003e1\u003c\/sup\u003e and for the hyaluronidase-inhibition mechanism class among triterpene saponins\u003csup\u003e2\u003c\/sup\u003e. Multi-Weight Hyaluronic Acid pairs surface and stratum-corneum-penetrating molecular weights for periorbital humectant support\u003csup\u003e3\u003c\/sup\u003e. The Natural Ceramide Complex of Glycosphingolipids and Glycolipids provides barrier lipid support documented in cosmetic dermatology literature, and Black Tea Leaf Extract contributes theaflavin and polyphenol antioxidant support.\u003c\/p\u003e\n\u003col class=\"op-refs\"\u003e\n\u003cli\u003eGallelli L. Escin: a review of its anti-edematous, anti-inflammatory, and venotonic properties. Drug Design, Development and Therapy. 2019;13:3425-3437. DOI 10.2147\/DDDT.S207720. PubMed PMID 31631970.\u003c\/li\u003e\n\u003cli\u003eFacino RM, Carini M, Stefani R, Aldini G, Saibene L. Anti-elastase and anti-hyaluronidase activities of saponins and sapogenins from Hedera helix, Aesculus hippocastanum, and Ruscus aculeatus. Archiv der Pharmazie. 1995;328(10):720-4. DOI 10.1002\/ardp.19953281006. PubMed PMID 8554461.\u003c\/li\u003e\n\u003cli\u003ePavicic T, Gauglitz GG, Lersch P, et al. Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. Journal of Drugs in Dermatology. 2011;10(9):990-1000. PubMed PMID 22052267.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"op-cite\"\u003eHow to cite this product page: Opuliss. Barrier Eye Cream. Opuliss Skin product page. 2026. https:\/\/opuliss.com\/products\/smoothing-eye-cream\u003c\/p\u003e","brand":"Opuliss Beauty","offers":[{"title":"Default","offer_id":52244844085522,"sku":"193039","price":84.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/9195\/5986\/files\/smoothing-eye-cream-square.jpg?v=1789187734"},{"product_id":"retinol-alternative-eye-serum","title":"CELLULAR ANTI-AGING BIORETINOL EYE SERUM","description":"\u003ch3\u003eThe Formula\u003c\/h3\u003e\n\u003cp\u003eA 15 ml \/ 0.51 fl oz periorbital serum built on a five-active stack: Bidens Pilosa Extract, a plant-based retinol alternative that anchors the Bioretinol line, Dipalmitoyl Hydroxyproline, a collagen amino acid ester, Alteromonas Ferment Extract\u003csup\u003e3\u003c\/sup\u003e, a deep-sea marine ferment, Escin within Aesculus Hippocastanum (Horse Chestnut) Seed Extract, and Borago Officinalis (Borage) Seed Oil, with Multi-Weight Hyaluronic Acid. 100% natural origin, 22% organic origin, vegan eligible.\u003c\/p\u003e\n\u003ch3\u003eHow It Works\u003c\/h3\u003e\n\u003cp\u003e\u003cem\u003eFormulated for Anti-Aging, Dry Skin, and Sensitive Skin.\u003c\/em\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eBidens Pilosa Extract, a botanical retinol alternative, combined with andrographolide, improved the look of wrinkles in various areas in a human clinical trial without irritation\u003csup\u003e1\u003c\/sup\u003e.\u003c\/li\u003e\n\u003cli\u003eEscin from Horse Chestnut Seed Extract, a triterpene saponin, supports the appearance of vascular dark circles under the eye\u003csup\u003e2\u003c\/sup\u003e.\u003c\/li\u003e\n\u003cli\u003eMulti-Weight Hyaluronic Acid, pairing surface and penetrating molecular weights, hydrates and visibly smooths.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003csmall\u003eHero mechanism: Bidens Pilosa Extract activates retinoid X receptor (RXR) alpha and supports extracellular matrix gene expression in laboratory models. Full mechanism and citations under Details and references.\u003c\/small\u003e\u003c\/p\u003e\n\u003ch3\u003eIngredients\u003c\/h3\u003e\n\u003cp\u003eBidens Pilosa Extract (Plant-Based Retinol Alternative), Dipalmitoyl Hydroxyproline (Collagen Amino Acid Ester), Alteromonas Ferment Extract, Escin + Aesculus Hippocastanum (Horse Chestnut) Seed Extract, Borago Officinalis (Borage) Seed Oil, Multi-Weight Hydrolyzed Hyaluronic Acid + Sodium Hyaluronate.\u003c\/p\u003e\n\u003cp\u003eActive ingredients: Bidens Pilosa Extract (a botanical RXR-pathway alternative); Dipalmitoyl Hydroxyproline (a collagen amino acid ester); Escin from Horse Chestnut Seed Extract (a triterpene saponin).\u003c\/p\u003e\n\u003ch3\u003eHow to Use\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eDispense a rice-grain quantity onto the ring finger and pat gently along the orbital bone from the inner corner outward.\u003c\/li\u003e\n\u003cli\u003eUse morning and evening after cleansing, before moisturiser or SPF.\u003c\/li\u003e\n\u003cli\u003eAllow 30 seconds to absorb before layering serums or sunscreen.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSafety\u003c\/h3\u003e\n\u003cp\u003e100% natural origin, 22% organic origin, vegan eligible. Asteraceae botanical disclosure: this product contains Bidens Pilosa Extract from the Asteraceae (daisy) plant family, which includes beneficial botanicals (chamomile, calendula, helichrysum) and common allergens including ragweed. Users with a known sensitivity to plants in this family (ragweed, chamomile, arnica, chrysanthemum, marigold, echinacea, or yarrow) may be at higher risk of contact sensitivity. Contains naturally occurring fragrance allergens (Geraniol, Citronellol, Linalool, Citral). Patch test on the inner forearm for 24 hours before periorbital use, and avoid direct contact with the eye surface. Pregnancy and nursing topical safety data is insufficient for the active stack at cosmetic concentrations. Consult a healthcare provider before use.\u003c\/p\u003e\n\u003ch3\u003eReferences\u003c\/h3\u003e\n\u003cp\u003eBidens Pilosa Extract supplies the botanical retinoid-pathway mechanism class. Ye 2025 reported that a fixed-combination test cream of 0.035% andrographolide plus 0.35% Bidens Pilosa Extract activated retinoid X receptor (RXR) alpha and enhanced extracellular matrix protein gene expression in dermal fibroblast and keratinocyte models. The human clinical cohort (n=14 crow's feet, n=13 under-eye, 4-week split-face versus a 0.1% retinol comparator) showed wrinkle, elasticity, and hydration improvements without irritating side effects\u003csup\u003e1\u003c\/sup\u003e. The clinical signal is fixed-combination, not Bidens monotherapy. Dieamant 2015 separately documented a standardised supercritical CO2 Bidens extract modulating RXR and RAR receptor expression in human dermal fibroblasts and ex vivo human skin fragments\u003csup\u003e4\u003c\/sup\u003e. Escin from Horse Chestnut Seed Extract is documented for reducing vascular permeability and for anti-edematous properties\u003csup\u003e2\u003c\/sup\u003e. Borago Officinalis Seed Oil delivers gamma-linolenic acid, an essential fatty acid studied in dermatology\u003csup\u003e5\u003c\/sup\u003e. Multi-Weight Hyaluronic Acid pairs surface-hydrating and stratum-corneum-penetrating molecular weights\u003csup\u003e6\u003c\/sup\u003e.\u003c\/p\u003e\n\u003col class=\"op-refs\"\u003e\n\u003cli\u003eYe S, Lee S, Kang S, Jun SH, Kang NG. Improvement of Skin Condition Through RXR Alpha-Activating Materials. Biomolecules. 2025;15(2):296. DOI 10.3390\/biom15020296. PubMed PMID 40001599.\u003c\/li\u003e\n\u003cli\u003eGallelli L. Escin: a review of its anti-edematous, anti-inflammatory, and venotonic properties. Drug Design, Development and Therapy. 2019;13:3425-3437. DOI 10.2147\/DDDT.S207720. PubMed PMID 31631970.\u003c\/li\u003e\n\u003cli\u003eGarre A, Martinez-Masana G, Piquero-Casals J, Granger C. Redefining face contour with a novel anti-aging cosmetic product: an open-label, prospective clinical study. Clinical, Cosmetic and Investigational Dermatology. 2017;10:473-482. PubMed PMID 29180884.\u003c\/li\u003e\n\u003cli\u003eDieamant G, Pereda MdelC, Nogueira C, et al. Antiageing Mechanisms of a Standardized Supercritical CO2 Preparation of Black Jack (Bidens pilosa L.) in Human Fibroblasts and Skin Fragments. Evidence-Based Complementary and Alternative Medicine. 2015;2015:280529. DOI 10.1155\/2015\/280529. PubMed PMID 25883669.\u003c\/li\u003e\n\u003cli\u003eFenner J, Silverberg NB. Oral supplements in atopic dermatitis. Clinics in Dermatology. 2018;36(5):653-658. DOI 10.1016\/j.clindermatol.2018.05.010. PubMed PMID 30217278.\u003c\/li\u003e\n\u003cli\u003ePavicic T, Gauglitz GG, Lersch P, et al. Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. Journal of Drugs in Dermatology. 2011;10(9):990-1000. PubMed PMID 22052267.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"op-cite\"\u003eHow to cite this product page: Opuliss. Cellular Anti-Aging Bioretinol Eye Serum. Opuliss Skin product page. 2026. https:\/\/opuliss.com\/products\/retinol-alternative-eye-serum\u003c\/p\u003e","brand":"Opuliss Beauty","offers":[{"title":"Default","offer_id":52251138294034,"sku":"194181","price":162.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/9195\/5986\/files\/retinol-alternative-eye-serum-square.jpg?v=1789187621"},{"product_id":"caffeine-de-puff-eye-booster","title":"CAFFEINE DE-PUFF EYE BOOSTER","description":"\u003ch3\u003eThe Formula\u003c\/h3\u003e\n\u003cp\u003eThe Opuliss Skin Caffeine De-Puff Eye Booster is a 20 ml \/ 0.68 fl oz water-gel of 1% Caffeine in a Glycerin and Algin (marine biopolymer) matrix, with Cellulose Gum and botanical esters from rose and lavender for a light sensory finish. The formula is 99% natural origin, 11% organic origin, and vegan eligible.\u003c\/p\u003e\n\u003ch3\u003eHow It Works\u003c\/h3\u003e\n\u003cp\u003e\u003cem\u003eFormulated for Anti-Aging and Sensitive Skin.\u003c\/em\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eCaffeine at 1%, a methylxanthine, is documented to support the microcirculation of blood in the skin, for a smoother, more awake-looking under-eye.\u003csup\u003e1\u003c\/sup\u003e\n\u003c\/li\u003e\n\u003cli\u003eAlgin, an algae-derived marine biopolymer, forms a lightweight gel with a smooth, surface-tightening finish and a mild soothing feel, suited to sensitive skin.\u003c\/li\u003e\n\u003cli\u003eGlycerin, a humectant, draws in water for a fresh, hydrated finish, and the water-gel absorbs quickly to layer under any eye cream or serum.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003csmall\u003eHero mechanism: Caffeine is a methylxanthine documented in cosmetic dermatology literature to support the microcirculation of blood in the skin (Herman 2013). Full mechanism and citations under Details and references.\u003c\/small\u003e\u003c\/p\u003e\n\u003ch3\u003eIngredients\u003c\/h3\u003e\n\u003cp\u003eAqua\/Water, Glycerin, Caffeine, Cellulose Gum, Algin, Geranyl Acetate, Linalyl Acetate.\u003c\/p\u003e\n\u003cp\u003eActive ingredients: Caffeine at 1%, a microcirculation-supporting methylxanthine; Algin, an algae-derived marine biopolymer and soothing gel-former; Glycerin, a humectant.\u003c\/p\u003e\n\u003ch3\u003eHow to Use\u003c\/h3\u003e\n\u003cp\u003eDispense one to two drops onto the ring finger. Pat gently along the orbital bone from the inner corner outward, without pulling the periorbital skin. Use morning and evening after cleansing, before eye cream or facial moisturiser. Allow about 30 seconds to absorb before layering serum or SPF.\u003c\/p\u003e\n\u003ch3\u003eSafety\u003c\/h3\u003e\n\u003cp\u003e99% natural origin, 11% organic origin, vegan eligible. Contains naturally occurring fragrance compounds (Geranyl Acetate, Linalyl Acetate). If you have a known fragrance allergy, patch test before regular use. Patch test on the inner forearm for 24 hours before periorbital application. Avoid direct contact with the eye surface.\u003c\/p\u003e\n\u003ch3\u003eReferences\u003c\/h3\u003e\n\u003cp\u003eCaffeine is a methylxanthine documented in cosmetic dermatology literature to support the microcirculation of blood in the skin, with dermocosmetic applications in the periorbital area.\u003csup\u003e1\u003c\/sup\u003e Algin is an algae-derived marine biopolymer that forms the smooth gel matrix and contributes a mild soothing feel. Glycerin is a humectant that supports a fresh, hydrated finish.\u003c\/p\u003e\n\u003col class=\"op-refs\"\u003e\n\u003cli\u003eHerman A, Herman AP. Caffeine's mechanisms of action and its cosmetic use. Skin Pharmacology and Physiology. 2013;26(1):8-14. DOI 10.1159\/000343174. PubMed PMID 23075568.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"op-cite\"\u003eHow to cite this product page: Opuliss. Caffeine De-Puff Eye Booster. Opuliss Skin product page. 2026. https:\/\/opuliss.com\/products\/caffeine-de-puff-eye-booster\u003c\/p\u003e","brand":"Opuliss Beauty","offers":[{"title":"Default","offer_id":52426479468818,"sku":"213120","price":217.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/9195\/5986\/files\/caffeine-de-puff-eye-booster-square.jpg?v=1789187017"},{"product_id":"cannabidiol-eye-cream-for-men","title":"CANNABIDIOL EYE CREAM FOR MEN","description":"\u003ch3\u003eThe Formula\u003c\/h3\u003e\n\u003cp\u003eA 15 ml \/ 0.51 fl oz leave-on eye cream for the male periorbital area, built on a six-active stack in a Cannabis Sativa (Hemp) Seed Oil base: Cannabidiol (CBD), Horse Chestnut Seed Extract standardised to escin, multi-weight Hyaluronic Acid, Grape Leaf Extract, Ginkgo Biloba Leaf Extract, and Wild Mango Kernel Butter. 99% natural origin, 18% organic origin, vegan eligible. Formulated with EU-compliant cannabidiol (CBD less than 0.001 percent THC).\u003c\/p\u003e\n\u003ch3\u003eHow It Works\u003c\/h3\u003e\n\u003cp\u003e\u003cem\u003eFormulated for Dry Skin, Redness and Rosacea, and Sensitive Skin.\u003c\/em\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eCannabidiol (CBD), a phytocannabinoid, interacts with the skin's cutaneous endocannabinoid system to support calming and comfort around the eye area.\u003c\/li\u003e\n\u003cli\u003eEscin, from Horse Chestnut Seed Extract, is vasoactive, documented for reducing vascular permeability and for anti-edematous properties\u003csup\u003e1\u003c\/sup\u003e.\u003c\/li\u003e\n\u003cli\u003eMulti-weight Hyaluronic Acid (Sodium Hyaluronate plus Hydrolyzed Hyaluronic Acid) holds hydration at multiple depths for a plumper, more hydrated look\u003csup\u003e2\u003c\/sup\u003e.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003csmall\u003eHero mechanism: cannabidiol interacts with the cutaneous endocannabinoid system (CB1\/CB2\/TRPV1\/PPAR-gamma) to support a calm, comfortable feel. Full mechanism and citations under Details and references.\u003c\/small\u003e\u003c\/p\u003e\n\u003ch3\u003eIngredients\u003c\/h3\u003e\n\u003cp\u003eCannabis Sativa Hemp Seed Oil + Cannabidiol (CBD), Wild Mango Kernel Butter, Horse Chestnut Seed Extract (Escin), Multi-Weight Hydrolyzed Hyaluronic Acid + Sodium Hyaluronate, Grape Leaf Extract, Ginkgo Biloba Leaf Extract.\u003c\/p\u003e\n\u003cp\u003eActive ingredients: Cannabidiol (CBD), a phytocannabinoid with a skin-calming role; Escin from Horse Chestnut, a triterpene saponin with a vasoactive periorbital role; Ginkgo Biloba Leaf Extract, a flavonoid antioxidant.\u003c\/p\u003e\n\u003ch3\u003eHow to Use\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eDispense one rice-grain amount onto the ring finger.\u003c\/li\u003e\n\u003cli\u003ePat gently along the orbital bone from the inner corner outward. Do not pull or stretch the skin.\u003c\/li\u003e\n\u003cli\u003eUse morning and evening after cleansing, before moisturiser or SPF. For external use only. Avoid direct contact with the eye surface.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSafety\u003c\/h3\u003e\n\u003cp\u003e99% natural origin, 18% organic origin, vegan eligible. Contains naturally derived fragrance compounds (Limonene, Linalool, Geraniol, and Citral). Patch test on the inner forearm for 24 hours before periorbital application. Cannabidiol is permitted in EU cosmetics. Avoid direct contact with the eye surface. Not recommended during pregnancy or nursing without dermatologist consultation.\u003c\/p\u003e\n\u003ch3\u003eReferences\u003c\/h3\u003e\n\u003cp\u003eEscin, a triterpene saponin from horse chestnut seed, supports vasoactive periorbital tone that helps reduce the look of puffiness\u003csup\u003e1\u003c\/sup\u003e. Multi-weight Hyaluronic Acid hydrates at multiple stratum corneum depths via molecular size variance for a plumper, more hydrated look\u003csup\u003e2\u003c\/sup\u003e. Ginkgo Biloba leaf extract contributes flavonoid antioxidant support\u003csup\u003e3\u003c\/sup\u003e.\u003c\/p\u003e\n\u003col class=\"op-refs\"\u003e\n\u003cli\u003eGallelli L. Escin: a review of its anti-edematous, anti-inflammatory, and venotonic properties. Drug Design, Development and Therapy. 2019;13:3425-3437. DOI 10.2147\/DDDT.S207720. PubMed PMID 31631970.\u003c\/li\u003e\n\u003cli\u003ePavicic T, Gauglitz GG, Lersch P, et al. Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. Journal of Drugs in Dermatology. 2011;10(9):990-1000. PubMed PMID 22052267.\u003c\/li\u003e\n\u003cli\u003eAbdellatif AAH, Mohammed HA, Al-Khalaf AM, et al. Ginkgo biloba leaves extract's cosmeceutical evaluation on human volunteers. Drug Development and Industrial Pharmacy. 2023;49(3):1-12. DOI 10.1080\/03639045.2023.2204374. PubMed PMID 37074796.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"op-cite\"\u003eHow to cite this product page: Opuliss. Cannabidiol Eye Cream for Men. Opuliss Skin product page. 2026. https:\/\/opuliss.com\/products\/cannabidiol-eye-cream-for-men\u003c\/p\u003e","brand":"Opuliss Beauty","offers":[{"title":"Default","offer_id":52426481008914,"sku":"213121","price":84.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/9195\/5986\/files\/cannabidiol-eye-cream-for-men-square.jpg?v=1789187042"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/9195\/5986\/collections\/opuliss-collection-hero-eye-and-lip-editorial-2026-08-17.png?v=1789491295","url":"https:\/\/opuliss.com\/collections\/eye-and-lip.oembed","provider":"Opuliss Beauty","version":"1.0","type":"link"}