{"product_id":"natural-retinol-alternative-oil-serum","title":"CELLULAR ANTI-AGING BAKUCHIOL RENEWAL OIL","description":"\u003ch3\u003eThe Formula\u003c\/h3\u003e\n\u003cp\u003eA 30 ml \/ 1.01 fl oz dry-finish facial oil serum built on a hero composition of Bakuchiol, a photostable plant alternative to retinol, carried in a base of organic Jojoba Seed Oil with Evening Primrose, Rosehip, Strawberry, Raspberry, and Blueberry seed oils. 99% natural origin, 61% organic origin, vegan eligible.\u003c\/p\u003e\n\u003ch3\u003eHow It Works\u003c\/h3\u003e\n\u003cp\u003e\u003cem\u003eFormulated for Anti-Aging and Dry Skin.\u003c\/em\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eBakuchiol, a meroterpene phenol, helps improve the appearance of fine lines and uneven tone via the same retinoid pathway as retinol\u003csup\u003e1\u003c\/sup\u003e.\u003c\/li\u003e\n\u003cli\u003eOenothera Biennis (Evening Primrose) Oil, a skin-conditioning plant oil that carries gamma-linolenic acid, an essential fatty acid\u003csup\u003e2\u003c\/sup\u003e.\u003c\/li\u003e\n\u003cli\u003eRosa Canina (Rosehip) Fruit Oil, an emollient plant oil rich in linoleic and alpha-linolenic essential fatty acids, softens and conditions.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003csmall\u003eHero mechanism: Bakuchiol, a meroterpene phenol, engages the same downstream retinoid pathway in skin cells as retinol, with documented comparable performance on the appearance of fine lines and hyperpigmentation over 12 weeks. Full mechanism and citations under Details and references.\u003c\/small\u003e\u003c\/p\u003e\n\u003ch3\u003eIngredients\u003c\/h3\u003e\n\u003cp\u003eBakuchiol, Oenothera Biennis (Evening Primrose) Oil, Tocopherol, Rosa Canina (Rosehip) Fruit Oil.\u003c\/p\u003e\n\u003cp\u003eActive ingredients: Bakuchiol (a meroterpene phenol, retinoid-pathway plant active); Evening Primrose Oil (a skin-conditioning source of gamma-linolenic acid); Rosehip Fruit Oil (an emollient plant oil rich in essential fatty acids).\u003c\/p\u003e\n\u003ch3\u003eHow to Use\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eApply two to three drops to clean skin in the evening, pressing gently into the face and neck.\u003c\/li\u003e\n\u003cli\u003eLayer under or over your moisturiser. Bakuchiol is photostable and comfortable for daytime use.\u003c\/li\u003e\n\u003cli\u003eUse a broad-spectrum SPF daily as part of any anti-aging routine.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSafety\u003c\/h3\u003e\n\u003cp\u003e99% natural origin, 61% organic origin, vegan eligible. Contains naturally occurring fragrance allergens (Geraniol, Citronellol, Linalool, Geranyl Acetate). Bakuchiol does not share retinol's molecular structure. Topical bakuchiol pregnancy safety has not been formally established, so consult your dermatologist before use during pregnancy or nursing. Patch test on the inner forearm for 24 hours before facial use.\u003c\/p\u003e\n\u003ch3\u003eReferences\u003c\/h3\u003e\n\u003cp\u003eBakuchiol is a meroterpene phenol with no structural resemblance to retinoids, yet it engages the same downstream retinoid pathway in skin cells. Chaudhuri and Bojanowski 2014 demonstrated, via comparative gene expression profiling in skin substitute models and human dermal fibroblasts, that bakuchiol modulates the same gene expression profile as retinol\u003csup\u003e3\u003c\/sup\u003e. In a 12-week prospective, randomised, double-blind clinical trial, 0.5% bakuchiol twice daily and 0.5% retinol daily both significantly decreased wrinkle surface area and the appearance of hyperpigmentation with no statistical difference. Bakuchiol users reported less facial scaling and stinging. That evidence is specific to 0.5% bakuchiol versus 0.5% retinol\u003csup\u003e1\u003c\/sup\u003e. Evening primrose oil delivers gamma-linolenic acid documented in dermatology reviews of dietary supplements. Topical evidence is mechanism-class plausibility\u003csup\u003e2\u003c\/sup\u003e. Lyons 2020 showed bakuchiol significantly improved the appearance of trichloroacetic-acid-induced post-inflammatory pigmentation versus vehicle and untreated control\u003csup\u003e4\u003c\/sup\u003e. Bakuchiol is photostable per the Sytheon Sytenol A Technical Data Sheet\u003csup\u003e5\u003c\/sup\u003e.\u003c\/p\u003e\n\u003col class=\"op-refs\"\u003e\n\u003cli\u003eDhaliwal S, Rybak I, Ellis SR, et al. Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing. British Journal of Dermatology. 2018;180(2):289-296. DOI 10.1111\/bjd.16918. PubMed PMID 29947134.\u003c\/li\u003e\n\u003cli\u003eFenner J, Silverberg NB. Oral supplements in atopic dermatitis. Clinics in Dermatology. 2018;36(5):653-658. DOI 10.1016\/j.clindermatol.2018.05.010. PubMed PMID 30217278.\u003c\/li\u003e\n\u003cli\u003eChaudhuri RK, Bojanowski K. Bakuchiol: a retinol-like functional compound revealed by gene expression profiling and clinically proven to have anti-aging effects. International Journal of Cosmetic Science. 2014;36(3):221-30. DOI 10.1111\/ics.12117. PubMed PMID 24471735.\u003c\/li\u003e\n\u003cli\u003eLyons AB, Kohli I, Nahhas AF, et al. Trichloroacetic acid model to accurately capture the efficacy of treatments for postinflammatory hyperpigmentation. Archives of Dermatological Research. 2020;312(10):725-730. DOI 10.1007\/s00403-020-02071-4. PubMed PMID 32253506.\u003c\/li\u003e\n\u003cli\u003eSytheon Ltd. Sytenol A Technical Data Sheet. 2024. Photostability and recommended use level 0.5 to 1%.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"op-cite\"\u003eHow to cite this product page: Opuliss. Cellular Anti-Aging Bakuchiol Renewal Oil. Opuliss Skin product page. 2026. https:\/\/opuliss.com\/products\/natural-retinol-alternative-oil-serum\u003c\/p\u003e","brand":"Opuliss Beauty","offers":[{"title":"Default","offer_id":52254749819154,"sku":"194501","price":295.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/9195\/5986\/files\/natural-retinol-alternative-oil-serum-corrected-sq.png?v=1789184290","url":"https:\/\/opuliss.com\/products\/natural-retinol-alternative-oil-serum","provider":"Opuliss Beauty","version":"1.0","type":"link"}