{"product_id":"retinol-alternative-eye-serum","title":"CELLULAR ANTI-AGING BIORETINOL EYE SERUM","description":"\u003ch3\u003eThe Formula\u003c\/h3\u003e\n\u003cp\u003eA 15 ml \/ 0.51 fl oz periorbital serum built on a five-active stack: Bidens Pilosa Extract, a plant-based retinol alternative that anchors the Bioretinol line, Dipalmitoyl Hydroxyproline, a collagen amino acid ester, Alteromonas Ferment Extract\u003csup\u003e3\u003c\/sup\u003e, a deep-sea marine ferment, Escin within Aesculus Hippocastanum (Horse Chestnut) Seed Extract, and Borago Officinalis (Borage) Seed Oil, with Multi-Weight Hyaluronic Acid. 100% natural origin, 22% organic origin, vegan eligible.\u003c\/p\u003e\n\u003ch3\u003eHow It Works\u003c\/h3\u003e\n\u003cp\u003e\u003cem\u003eFormulated for Anti-Aging, Dry Skin, and Sensitive Skin.\u003c\/em\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eBidens Pilosa Extract, a botanical retinol alternative, combined with andrographolide, improved the look of wrinkles in various areas in a human clinical trial without irritation\u003csup\u003e1\u003c\/sup\u003e.\u003c\/li\u003e\n\u003cli\u003eEscin from Horse Chestnut Seed Extract, a triterpene saponin, supports the appearance of vascular dark circles under the eye\u003csup\u003e2\u003c\/sup\u003e.\u003c\/li\u003e\n\u003cli\u003eMulti-Weight Hyaluronic Acid, pairing surface and penetrating molecular weights, hydrates and visibly smooths.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003csmall\u003eHero mechanism: Bidens Pilosa Extract activates retinoid X receptor (RXR) alpha and supports extracellular matrix gene expression in laboratory models. Full mechanism and citations under Details and references.\u003c\/small\u003e\u003c\/p\u003e\n\u003ch3\u003eIngredients\u003c\/h3\u003e\n\u003cp\u003eBidens Pilosa Extract (Plant-Based Retinol Alternative), Dipalmitoyl Hydroxyproline (Collagen Amino Acid Ester), Alteromonas Ferment Extract, Escin + Aesculus Hippocastanum (Horse Chestnut) Seed Extract, Borago Officinalis (Borage) Seed Oil, Multi-Weight Hydrolyzed Hyaluronic Acid + Sodium Hyaluronate.\u003c\/p\u003e\n\u003cp\u003eActive ingredients: Bidens Pilosa Extract (a botanical RXR-pathway alternative); Dipalmitoyl Hydroxyproline (a collagen amino acid ester); Escin from Horse Chestnut Seed Extract (a triterpene saponin).\u003c\/p\u003e\n\u003ch3\u003eHow to Use\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eDispense a rice-grain quantity onto the ring finger and pat gently along the orbital bone from the inner corner outward.\u003c\/li\u003e\n\u003cli\u003eUse morning and evening after cleansing, before moisturiser or SPF.\u003c\/li\u003e\n\u003cli\u003eAllow 30 seconds to absorb before layering serums or sunscreen.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSafety\u003c\/h3\u003e\n\u003cp\u003e100% natural origin, 22% organic origin, vegan eligible. Asteraceae botanical disclosure: this product contains Bidens Pilosa Extract from the Asteraceae (daisy) plant family, which includes beneficial botanicals (chamomile, calendula, helichrysum) and common allergens including ragweed. Users with a known sensitivity to plants in this family (ragweed, chamomile, arnica, chrysanthemum, marigold, echinacea, or yarrow) may be at higher risk of contact sensitivity. Contains naturally occurring fragrance allergens (Geraniol, Citronellol, Linalool, Citral). Patch test on the inner forearm for 24 hours before periorbital use, and avoid direct contact with the eye surface. Pregnancy and nursing topical safety data is insufficient for the active stack at cosmetic concentrations. Consult a healthcare provider before use.\u003c\/p\u003e\n\u003ch3\u003eReferences\u003c\/h3\u003e\n\u003cp\u003eBidens Pilosa Extract supplies the botanical retinoid-pathway mechanism class. Ye 2025 reported that a fixed-combination test cream of 0.035% andrographolide plus 0.35% Bidens Pilosa Extract activated retinoid X receptor (RXR) alpha and enhanced extracellular matrix protein gene expression in dermal fibroblast and keratinocyte models. The human clinical cohort (n=14 crow's feet, n=13 under-eye, 4-week split-face versus a 0.1% retinol comparator) showed wrinkle, elasticity, and hydration improvements without irritating side effects\u003csup\u003e1\u003c\/sup\u003e. The clinical signal is fixed-combination, not Bidens monotherapy. Dieamant 2015 separately documented a standardised supercritical CO2 Bidens extract modulating RXR and RAR receptor expression in human dermal fibroblasts and ex vivo human skin fragments\u003csup\u003e4\u003c\/sup\u003e. Escin from Horse Chestnut Seed Extract is documented for reducing vascular permeability and for anti-edematous properties\u003csup\u003e2\u003c\/sup\u003e. Borago Officinalis Seed Oil delivers gamma-linolenic acid, an essential fatty acid studied in dermatology\u003csup\u003e5\u003c\/sup\u003e. Multi-Weight Hyaluronic Acid pairs surface-hydrating and stratum-corneum-penetrating molecular weights\u003csup\u003e6\u003c\/sup\u003e.\u003c\/p\u003e\n\u003col class=\"op-refs\"\u003e\n\u003cli\u003eYe S, Lee S, Kang S, Jun SH, Kang NG. Improvement of Skin Condition Through RXR Alpha-Activating Materials. Biomolecules. 2025;15(2):296. DOI 10.3390\/biom15020296. PubMed PMID 40001599.\u003c\/li\u003e\n\u003cli\u003eGallelli L. Escin: a review of its anti-edematous, anti-inflammatory, and venotonic properties. Drug Design, Development and Therapy. 2019;13:3425-3437. DOI 10.2147\/DDDT.S207720. PubMed PMID 31631970.\u003c\/li\u003e\n\u003cli\u003eGarre A, Martinez-Masana G, Piquero-Casals J, Granger C. Redefining face contour with a novel anti-aging cosmetic product: an open-label, prospective clinical study. Clinical, Cosmetic and Investigational Dermatology. 2017;10:473-482. PubMed PMID 29180884.\u003c\/li\u003e\n\u003cli\u003eDieamant G, Pereda MdelC, Nogueira C, et al. Antiageing Mechanisms of a Standardized Supercritical CO2 Preparation of Black Jack (Bidens pilosa L.) in Human Fibroblasts and Skin Fragments. Evidence-Based Complementary and Alternative Medicine. 2015;2015:280529. DOI 10.1155\/2015\/280529. PubMed PMID 25883669.\u003c\/li\u003e\n\u003cli\u003eFenner J, Silverberg NB. Oral supplements in atopic dermatitis. Clinics in Dermatology. 2018;36(5):653-658. DOI 10.1016\/j.clindermatol.2018.05.010. PubMed PMID 30217278.\u003c\/li\u003e\n\u003cli\u003ePavicic T, Gauglitz GG, Lersch P, et al. Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. Journal of Drugs in Dermatology. 2011;10(9):990-1000. PubMed PMID 22052267.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"op-cite\"\u003eHow to cite this product page: Opuliss. Cellular Anti-Aging Bioretinol Eye Serum. Opuliss Skin product page. 2026. https:\/\/opuliss.com\/products\/retinol-alternative-eye-serum\u003c\/p\u003e","brand":"Opuliss Beauty","offers":[{"title":"Default","offer_id":52251138294034,"sku":"194181","price":162.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/9195\/5986\/files\/retinol-alternative-eye-serum-square.jpg?v=1789187621","url":"https:\/\/opuliss.com\/products\/retinol-alternative-eye-serum","provider":"Opuliss Beauty","version":"1.0","type":"link"}