{"product_id":"retinol-alternative-moisturiser","title":"CELLULAR ANTI-AGING BIORETINOL DAILY CREAM","description":"\u003ch3\u003eThe Formula\u003c\/h3\u003e\n\u003cp\u003eA 50 ml \/ 1.69 fl oz daytime cream built on a five-active stack: Bidens Pilosa Extract (a botanical retinol alternative), Dipalmitoyl Hydroxyproline (a collagen amino acid ester), Alteromonas Ferment Extract (a marine ferment), Rose Myrtle Fruit Extract, and Sea Buckthorn Fruit Extract, with multi-weight Hyaluronic Acid and Murumuru Seed Butter. 99% natural origin, 23% organic origin, vegan eligible.\u003c\/p\u003e\n\u003ch3\u003eHow It Works\u003c\/h3\u003e\n\u003cp\u003e\u003cem\u003eFormulated for Acne Prone and Anti-Aging skin.\u003c\/em\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eBidens Pilosa Extract, a botanical retinol alternative, combined with andrographolide, improved the look of wrinkles, elasticity and hydration in a human trial without irritation\u003csup\u003e1\u003c\/sup\u003e.\u003c\/li\u003e\n\u003cli\u003eSea Buckthorn Fruit Extract supports the appearance of the skin barrier through its flavonoids\u003csup\u003e2\u003c\/sup\u003e.\u003c\/li\u003e\n\u003cli\u003eMulti-weight Hyaluronic Acid holds hydration at multiple depths for a plumper, more hydrated look\u003csup\u003e3\u003c\/sup\u003e.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003csmall\u003eHero mechanism: Bidens Pilosa Extract was studied in a fixed combination for RXR alpha activation and extracellular matrix gene expression in cell models. Full mechanism and citations under Details and references.\u003c\/small\u003e\u003c\/p\u003e\n\u003ch3\u003eIngredients\u003c\/h3\u003e\n\u003cp\u003eBidens Pilosa Extract (Plant-Based Retinol Alternative), Dipalmitoyl Hydroxyproline (Collagen Amino Acid Ester), Alteromonas Ferment Extract (Marine Ferment), Rose Myrtle Fruit Extract, Sea Buckthorn Fruit Extract, Multi-Weight Hydrolyzed Hyaluronic Acid + Sodium Hyaluronate.\u003c\/p\u003e\n\u003cp\u003eActive ingredients: Bidens Pilosa Extract, a botanical RXR pathway activator; Dipalmitoyl Hydroxyproline, a collagen amino acid ester; Alteromonas Ferment Extract\u003csup\u003e4\u003c\/sup\u003e, a marine ferment.\u003c\/p\u003e\n\u003ch3\u003eHow to Use\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eApply in the morning to clean skin after toner and serum. Press gently into face and neck.\u003c\/li\u003e\n\u003cli\u003eLayer with broad-spectrum SPF 30 or higher daily.\u003c\/li\u003e\n\u003cli\u003eCompatible with your other Opuliss Skin actives, including salicylic acid in an evening routine.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSafety\u003c\/h3\u003e\n\u003cp\u003e99% natural origin, 23% organic origin, vegan eligible. Contains Bidens Pilosa Extract, from the Asteraceae (daisy) plant family. If you have a known sensitivity to ragweed, chamomile, arnica, chrysanthemum, marigold, echinacea, or yarrow, patch test on the inner forearm for 24 hours before facial use. Contains naturally occurring fragrance allergens (Geraniol, Citronellol, Linalool, Citral).\u003c\/p\u003e\n\u003ch3\u003eReferences\u003c\/h3\u003e\n\u003cp\u003eBidens Pilosa Extract delivers a botanical retinoid-pathway mechanism. Ye 2025 showed a fixed combination activated retinoid X receptor (RXR) alpha and enhanced extracellular matrix gene expression in cell models, with a small clinical cohort reporting improvements in the look of wrinkles, elasticity, and hydration without irritating side effects\u003csup\u003e1\u003c\/sup\u003e. Sea Buckthorn Fruit Extract supports the appearance of barrier comfort via its flavonoid antioxidants\u003csup\u003e2\u003c\/sup\u003e. Multi-weight Hyaluronic Acid hydrates at multiple stratum corneum depths via molecular size variance\u003csup\u003e3\u003c\/sup\u003e.\u003c\/p\u003e\n\u003col class=\"op-refs\"\u003e\n\u003cli\u003eYe S, Lee S, Kang S, Jun SH, Kang NG. Improvement of Skin Condition Through RXR Alpha-Activating Materials. Biomolecules. 2025;15(2):296. DOI 10.3390\/biom15020296. PubMed PMID 40001599.\u003c\/li\u003e\n\u003cli\u003eGu Y, Wang X, Liu F, et al. Total flavonoids of sea buckthorn (Hippophae rhamnoides L.) improve MC903-induced atopic dermatitis-like lesions. Journal of Ethnopharmacology. 2022;292:115195. DOI 10.1016\/j.jep.2022.115195. PubMed PMID 35306042.\u003c\/li\u003e\n\u003cli\u003eNi C, Zhang Z, Wang Y, et al. Hyaluronic acid and HA-modified cationic liposomes for promoting skin penetration and retention. Journal of Controlled Release. 2023;357:432-443. DOI 10.1016\/j.jconrel.2023.03.049. PubMed PMID 37004799.\u003c\/li\u003e\n\u003cli\u003eGarre A, Martinez-Masana G, Piquero-Casals J, Granger C. Redefining face contour with a novel anti-aging cosmetic product: an open-label, prospective clinical study. Clinical, Cosmetic and Investigational Dermatology. 2017;10:473-482. PubMed PMID 29180884.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"op-cite\"\u003eHow to cite this product page: Opuliss. Cellular Anti-Aging Bioretinol Daily Cream. Opuliss Skin product page. 2026. https:\/\/opuliss.com\/products\/retinol-alternative-moisturiser\u003c\/p\u003e","brand":"Opuliss Beauty","offers":[{"title":"Default","offer_id":52238321221906,"sku":"191723","price":281.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/9195\/5986\/files\/retinol-alternative-moisturiser-square.jpg?v=1789187630","url":"https:\/\/opuliss.com\/products\/retinol-alternative-moisturiser","provider":"Opuliss Beauty","version":"1.0","type":"link"}