{"product_id":"retinol-alternative-serum","title":"CELLULAR ANTI-AGING BIORETINOL SERUM","description":"\u003ch3\u003eThe Formula\u003c\/h3\u003e\n\u003cp\u003eA 30 ml \/ 1.01 fl oz plant-retinoid serum built on a five-active stack led by Bidens Pilosa Extract, a plant-based retinol alternative, with Rose Myrtle Fruit Extract, Sea Buckthorn Fruit Extract, Rosehip Fruit Oil, and Murumuru Seed Butter, plus Multi-Weight Hyaluronic Acid. 99% natural origin, 24% organic origin, vegan eligible.\u003c\/p\u003e\n\u003ch3\u003eHow It Works\u003c\/h3\u003e\n\u003cp\u003e\u003cem\u003eFormulated for Anti-Aging.\u003c\/em\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eBidens Pilosa Extract, a retinol alternative, combined with andrographolide, improved the look of wrinkles, elasticity and hydration in a human trial without retinol's typical irritation\u003csup\u003e1\u003c\/sup\u003e.\u003c\/li\u003e\n\u003cli\u003eRhodomyrtus Tomentosa (Rose Myrtle) Fruit Extract, a phenolic antioxidant, supports the skin against the appearance of environmental stress.\u003c\/li\u003e\n\u003cli\u003eHippophae Rhamnoides (Sea Buckthorn) Fruit Extract helps support the appearance of the skin barrier through its flavonoids\u003csup\u003e2\u003c\/sup\u003e.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003csmall\u003eHero mechanism: Bidens Pilosa Extract, a botanical RXR-pathway active, activates the retinoid X receptor (RXR) alpha pathway associated with the appearance of firmer, smoother skin. Full mechanism and citations under Details and references.\u003c\/small\u003e\u003c\/p\u003e\n\u003ch3\u003eIngredients\u003c\/h3\u003e\n\u003cp\u003eBidens Pilosa Extract (Plant-Based Retinol Alternative), Rhodomyrtus Tomentosa (Rose Myrtle) Fruit Extract, Hippophae Rhamnoides (Sea Buckthorn) Fruit Extract, Rosa Canina (Rosehip) Fruit Oil, Astrocaryum Murumuru Seed Butter, Multi-Weight Hydrolyzed Hyaluronic Acid + Sodium Hyaluronate.\u003c\/p\u003e\n\u003cp\u003eActive ingredients: Bidens Pilosa Extract (a botanical RXR-pathway active); Rose Myrtle Fruit Extract (a phenolic antioxidant); Sea Buckthorn Fruit Extract (a flavonoid antioxidant).\u003c\/p\u003e\n\u003ch3\u003eHow to Use\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eApply two to three drops to clean skin morning and evening, pressing into the face and neck.\u003c\/li\u003e\n\u003cli\u003eLayer under moisturiser.\u003c\/li\u003e\n\u003cli\u003eApply a broad-spectrum SPF 30 or higher daily.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSafety\u003c\/h3\u003e\n\u003cp\u003e99% natural origin, 24% organic origin, vegan eligible. Asteraceae botanical disclosure: this product contains Bidens Pilosa Extract from the Asteraceae (daisy) plant family, which includes beneficial botanicals (chamomile, calendula, helichrysum) and common allergens including ragweed. Users with a known sensitivity to plants in this family (ragweed, chamomile, arnica, chrysanthemum, marigold, echinacea, or yarrow) may be at higher risk of contact sensitivity. Contains naturally occurring fragrance allergens (Geraniol, Citronellol, Linalool, Citral). Patch test on the inner forearm for 24 hours before facial use.\u003c\/p\u003e\n\u003ch3\u003eReferences\u003c\/h3\u003e\n\u003cp\u003eBidens Pilosa Extract delivers the botanical retinoid-pathway approach. Ye 2025 showed that a fixed-combination test cream of 0.035% andrographolide plus 0.35% Bidens Pilosa Extract activated retinoid X receptor (RXR) alpha and enhanced extracellular matrix protein gene expression in dermal fibroblast and keratinocyte models. The human clinical cohort (n=14 crow's feet, 4-week split-face versus 0.1% retinol comparator) showed wrinkle, elasticity, and hydration improvements without irritating side effects\u003csup\u003e1\u003c\/sup\u003e. The clinical signal is fixed-combination, not Bidens monotherapy. Dieamant 2015 separately documented a standardised supercritical CO2 Bidens extract modulating RXR and RAR receptor expression in human dermal fibroblasts and ex vivo human skin fragments\u003csup\u003e3\u003c\/sup\u003e. Hippophae Rhamnoides (Sea Buckthorn) Fruit Extract supports the appearance of the skin barrier via a flavonoid and carotenoid antioxidant composition. Gu 2022 studied Total Flavonoids of Hippophae rhamnoides (TFH), an isolated flavonoid fraction at 0.5% and 1% TFH cream that is chemically distinct from whole Fruit Extract, so the mechanism class extends to the whole Fruit Extract in this product at supporting tier only\u003csup\u003e2\u003c\/sup\u003e. Rosa Canina (Rosehip) Fruit Oil, an emollient plant oil, conditions the skin through its linoleic and alpha-linolenic essential fatty acid composition. Multi-Weight Hyaluronic Acid pairs surface-hydrating and stratum-corneum-penetrating molecular weights\u003csup\u003e4\u003c\/sup\u003e.\u003c\/p\u003e\n\u003col class=\"op-refs\"\u003e\n\u003cli\u003eYe S, Lee S, Kang S, Jun SH, Kang NG. Improvement of Skin Condition Through RXR Alpha-Activating Materials. Biomolecules. 2025;15(2):296. DOI 10.3390\/biom15020296. PubMed PMID 40001599.\u003c\/li\u003e\n\u003cli\u003eGu Y, Wang X, Liu F, et al. Total flavonoids of sea buckthorn (Hippophae rhamnoides L.) improve MC903-induced atopic dermatitis-like lesions. Journal of Ethnopharmacology. 2022;292:115195. DOI 10.1016\/j.jep.2022.115195. PubMed PMID 35306042.\u003c\/li\u003e\n\u003cli\u003eDieamant G, Pereda MdelC, Nogueira C, et al. Antiageing Mechanisms of a Standardized Supercritical CO2 Preparation of Black Jack (Bidens pilosa L.) in Human Fibroblasts and Skin Fragments. Evidence-Based Complementary and Alternative Medicine. 2015;2015:280529. DOI 10.1155\/2015\/280529. PubMed PMID 25883669.\u003c\/li\u003e\n\u003cli\u003ePavicic T, Gauglitz GG, Lersch P, et al. Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. Journal of Drugs in Dermatology. 2011;10(9):990-1000. PubMed PMID 22052267.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp class=\"op-cite\"\u003eHow to cite this product page: Opuliss. Cellular Anti-Aging Bioretinol Serum. Opuliss Skin product page. 2026. https:\/\/opuliss.com\/products\/retinol-alternative-serum\u003c\/p\u003e","brand":"Opuliss Beauty","offers":[{"title":"Default","offer_id":52251141013778,"sku":"194182","price":325.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/9195\/5986\/files\/retinol-alternative-serum-corrected-sq.png?v=1789193489","url":"https:\/\/opuliss.com\/products\/retinol-alternative-serum","provider":"Opuliss Beauty","version":"1.0","type":"link"}