POSTBIOTIC CALM MIST
A microbiome-supportive face mist for dry, sensitive skin. A Lactobacillus ferment lysate postbiotic pairs with a rhamnose, glucose, and glucuronic acid prebiotic complex and multi-weight hyaluronic acid, delivering weightless hydration that layers cleanly under serum, moisturiser, and makeup.
Backed by published research · references belowFormulated for Dry Skin and Sensitive Skin.
- Lactobacillus Ferment Lysate, a postbiotic (an inanimate microbial lysate, distinct from a live probiotic), supports skin barrier function and surface comfort1.
- Microbiome Prebiotic Complex (Rhamnose, Glucose, Glucuronic Acid), three sugar substrates for resident commensal skin bacteria.
- Multi-Weight Hyaluronic Acid, a glycosaminoglycan humectant naturally present in skin that can hold up to 1,000 times its weight in water2.
Hero mechanism: Lactobacillus Ferment Lysate, a postbiotic, releases intracellular and extracellular metabolic contents when the fermented bacteria are lysed. No viable cells remain in the finished product. Full mechanism and citations under Details and references.
A 100 ml / 3.38 fl oz microbiome-supportive face mist built on a four-active stack: Lactobacillus Ferment Lysate (a postbiotic), Hydrolyzed Glycosaminoglycans, a Microbiome Prebiotic Complex of Rhamnose, Glucose, and Glucuronic Acid, and Multi-Weight Hyaluronic Acid (Hydrolyzed Hyaluronic Acid plus Sodium Hyaluronate). 99% natural origin, 7% organic origin, vegan eligible.
Lactobacillus Ferment Lysate (Postbiotic), Hydrolyzed Glycosaminoglycans, Rhamnose + Glucose + Glucuronic Acid (Microbiome Prebiotic Complex), Multi-Weight Hydrolyzed Hyaluronic Acid + Sodium Hyaluronate.
Active ingredients: Lactobacillus Ferment Lysate, a postbiotic (an inanimate microbial lysate) with a skin-conditioning function; Microbiome Prebiotic Complex (Rhamnose, Glucose, Glucuronic Acid), sugar substrates for resident commensal bacteria; Multi-Weight Hyaluronic Acid, a glycosaminoglycan humectant.
Aqua/Water, Alcohol, Parfum/Fragrance, Betaine, Lactobacillus Ferment Lysate, Sodium PCA, Hydrolyzed Glycosaminoglycans, Glycerin, Propanediol, Potassium Hydroxide, Potassium Sorbate, Sodium Benzoate, Hydrolyzed Hyaluronic Acid, Sodium Hyaluronate, Rhamnose, Glucose, Glucuronic Acid
The ingredient list printed on your product’s packaging is always definitive; where it differs from this page, the packaging prevails.
- Hold the bottle 15 to 20 centimetres from the face and mist evenly.
- Use as a morning or midday refresh, after cleansing, or after exercise. It layers cleanly under serum, moisturiser, and makeup.
- Suitable for daily use.
99% natural origin, 7% organic origin, vegan eligible. The formulation contains Alcohol at INCI position 2 as a co-solvent and preservative aid. At cosmetic-use concentration it does not produce the dehydrating profile of high-alcohol toners, and Parfum is present at fragrance levels. Patch test on the inner forearm for 24 hours before facial use. Avoid spraying directly into the eyes. Close the eyes during application.
Lactobacillus Ferment Lysate is a postbiotic (an inanimate microbial lysate) produced by mechanically lysing fermented Lactobacillus bacteria and is distinct from a live probiotic. EU CosIng lists it with a skin-conditioning function. Applied to reconstructed human epidermis, a Lactobacillus rhamnosus lysate supported skin barrier proteins including filaggrin, loricrin, and tight junction proteins1. Multi-Weight Hyaluronic Acid pairs Hydrolyzed Hyaluronic Acid with Sodium Hyaluronate. Hyaluronic acid is a glycosaminoglycan naturally present in skin that can hold up to 1,000 times its weight in water2. The Microbiome Prebiotic Complex (Rhamnose, Glucose, Glucuronic Acid) supplies three sugar substrates for resident commensal skin bacteria. In a 30-day randomised self-control study, a four-strain Lactobacillus lysate cosmetic blend improved transepidermal water loss and hydration endpoints in sensitive-skin subjects3.
- Jung YO, Jeong H, Cho Y, et al. Lysates of a Probiotic, Lactobacillus rhamnosus, Can Improve Skin Barrier Function in a Reconstructed Human Epidermis Model. International Journal of Molecular Sciences. 2019;20(17):4289. PubMed PMID 31480681.
- Papakonstantinou E, Roth M, Karakiulakis G. Hyaluronic acid: A key molecule in skin aging. Dermato-Endocrinology. 2012;4(3):253-258. DOI 10.4161/derm.21923.
- Cui H, Feng C, Zhang T, et al. Effects of a lotion containing probiotic ferment lysate as the main functional ingredient on enhancing skin barrier: a randomized, self-control study. Sci Rep. 2023;13(1):16879. DOI 10.1038/s41598-023-43336-y. PubMed PMID 37803101.
How to cite this product page: Opuliss. Postbiotic Calm Mist. Opuliss Skin product page. 2026. https://opuliss.com/products/microbiome-prebiotics-face-mist
The Science
Lactobacillus Ferment Lysate is a postbiotic studied in cosmetics for supporting the skin's barrier and reducing water loss, helping this mist refresh and calm the look of stressed skin.
Source: Cui H, et al. Scientific Reports, 2023 (PMID 37803101).
INSIDE THE SCIENCE
From precision-fermented actives to biomimetic complexes, discover what makes it Opuliss.
POSTBIOTIC FERMENT
A postbiotic that helps balance the microbiome and calm reactive skin.
Source: Cui H, et al. Scientific Reports, 2023 (PMID 37803101).
SKIN-IDENTICAL HYDRATORS
Skin-identical hydrators that bind water for plump, supple skin.
Source: Wang ST, et al. Clinical, Cosmetic and Investigational Dermatology, 2021 (PMID 34548803).
RHAMNOSE PREBIOTIC
A plant-derived prebiotic sugar that supports a balanced, comfortable skin microbiome.
HOW TO USE
Hold the bottle 15 to 20 centimetres from the face and mist evenly.
Use as a morning or midday refresh, after cleansing, or after exercise. It layers cleanly under serum, moisturiser, and makeup.
Suitable for daily use.
THE TEXTURE
The Opuliss difference
SCIENCE, MADE VISIBLE
Opuliss begins where the research ends. Every active is named, every claim is traceable, and nothing is left to promise alone.
Morning to night
A RITUAL, CONSIDERED
Each formula stands on its own and belongs to the whole. Layered with intention, morning and night, the routine becomes unmistakably yours.
A twenty four hour rhythm
THE SKIN KEEPS TIME
Skin is not the same at midnight as it is at nine in the morning. Across a single day its temperature, its acidity and the moisture it loses to the air each move on a rhythm of their own. Morning and night are not two routines. They are one, kept in time.
Yosipovitch G et al. Journal of Investigative Dermatology, 1998 (PMID 9424081). Sixteen volunteers sampled every two hours across a twenty four hour span.
