CELLULAR ANTI-AGING BIORETINOL EYE SERUM
A periorbital bioretinol eye serum for anti-aging, dry, and sensitive skin. Bidens Pilosa, a plant-based retinol alternative, supports the look of fine lines and firmness, escin from horse chestnut targets the appearance of dark circles, and multi-weight hyaluronic acid hydrates the delicate eye area.
Backed by published research · references belowHow subscriptions work
- Your ritual, uninterrupted. Each refill arrives before the last one runs out, at 20% off with complimentary shipping, every time.
- We email you ten days before each refill ships, and you are only billed on the day it ships.
- Pause, skip a delivery, or cancel whenever you wish. No minimum commitment.
Subscription pricing carries its own saving and does not combine with other offers or codes.
Formulated for Anti-Aging, Dry Skin, and Sensitive Skin.
- Bidens Pilosa Extract, a botanical retinol alternative, combined with andrographolide, improved the look of wrinkles in various areas in a human clinical trial without irritation1.
- Escin from Horse Chestnut Seed Extract, a triterpene saponin, supports the appearance of vascular dark circles under the eye2.
- Multi-Weight Hyaluronic Acid, pairing surface and penetrating molecular weights, hydrates and visibly smooths.
Hero mechanism: Bidens Pilosa Extract activates retinoid X receptor (RXR) alpha and supports extracellular matrix gene expression in laboratory models. Full mechanism and citations under Details and references.
A 15 ml / 0.51 fl oz periorbital serum built on a five-active stack: Bidens Pilosa Extract, a plant-based retinol alternative that anchors the Bioretinol line, Dipalmitoyl Hydroxyproline, a collagen amino acid ester, Alteromonas Ferment Extract3, a deep-sea marine ferment, Escin within Aesculus Hippocastanum (Horse Chestnut) Seed Extract, and Borago Officinalis (Borage) Seed Oil, with Multi-Weight Hyaluronic Acid. 100% natural origin, 22% organic origin, vegan eligible.
Bidens Pilosa Extract (Plant-Based Retinol Alternative), Dipalmitoyl Hydroxyproline (Collagen Amino Acid Ester), Alteromonas Ferment Extract, Escin + Aesculus Hippocastanum (Horse Chestnut) Seed Extract, Borago Officinalis (Borage) Seed Oil, Multi-Weight Hydrolyzed Hyaluronic Acid + Sodium Hyaluronate.
Active ingredients: Bidens Pilosa Extract (a botanical RXR-pathway alternative); Dipalmitoyl Hydroxyproline (a collagen amino acid ester); Escin from Horse Chestnut Seed Extract (a triterpene saponin).
Aloe Barbadensis (Aloe) Leaf Juice, Glycerin, Coconut Alkanes, Pentylene Glycol, Aqua/Water, Simmondsia Chinensis (Jojoba) Seed Oil, Sodium PCA, Polyglyceryl-6 Stearate, Glyceryl Stearate Citrate, Borago Officinalis (Borage) Seed Oil, Caprylic/Capric Triglyceride, Dipalmitoyl Hydroxyproline, Ricinus Communis (Castor) Seed Oil, Astrocaryum Murumuru Seed Butter, Gossypium Herbaceum Seed Oil, Bidens Pilosa Extract, Linum Usitatissimum Seed Oil, Parfum/Fragrance, CI 77163 (Bismuth Chloride Oxide), Polyglyceryl-6 Behenate, Rhus Verniciflua Peel Cera/Rhus Succedanea Fruit Cera, Xanthan Gum, Aesculus Hippocastanum (Horse Chestnut) Seed Extract, Cellulose, Tocopherol, Ascorbyl Palmitate, Potassium Hydroxide, Mangifera Indica (Mango) Seed Butter, Hydrolyzed Hyaluronic Acid, Sodium Hyaluronate, Sodium Phytate, Octyldodecanol, Alteromonas Ferment Extract, Phenethyl Alcohol, Escin, Geraniol, Citronellol, Pelargonium Graveolens Flower Oil, Linalool, Citral
The ingredient list printed on your product’s packaging is always definitive; where it differs from this page, the packaging prevails.
- Dispense a rice-grain quantity onto the ring finger and pat gently along the orbital bone from the inner corner outward.
- Use morning and evening after cleansing, before moisturiser or SPF.
- Allow 30 seconds to absorb before layering serums or sunscreen.
100% natural origin, 22% organic origin, vegan eligible. Asteraceae botanical disclosure: this product contains Bidens Pilosa Extract from the Asteraceae (daisy) plant family, which includes beneficial botanicals (chamomile, calendula, helichrysum) and common allergens including ragweed. Users with a known sensitivity to plants in this family (ragweed, chamomile, arnica, chrysanthemum, marigold, echinacea, or yarrow) may be at higher risk of contact sensitivity. Contains naturally occurring fragrance allergens (Geraniol, Citronellol, Linalool, Citral). Patch test on the inner forearm for 24 hours before periorbital use, and avoid direct contact with the eye surface. Pregnancy and nursing topical safety data is insufficient for the active stack at cosmetic concentrations. Consult a healthcare provider before use.
Bidens Pilosa Extract supplies the botanical retinoid-pathway mechanism class. Ye 2025 reported that a fixed-combination test cream of 0.035% andrographolide plus 0.35% Bidens Pilosa Extract activated retinoid X receptor (RXR) alpha and enhanced extracellular matrix protein gene expression in dermal fibroblast and keratinocyte models. The human clinical cohort (n=14 crow's feet, n=13 under-eye, 4-week split-face versus a 0.1% retinol comparator) showed wrinkle, elasticity, and hydration improvements without irritating side effects1. The clinical signal is fixed-combination, not Bidens monotherapy. Dieamant 2015 separately documented a standardised supercritical CO2 Bidens extract modulating RXR and RAR receptor expression in human dermal fibroblasts and ex vivo human skin fragments4. Escin from Horse Chestnut Seed Extract is documented for reducing vascular permeability and for anti-edematous properties2. Borago Officinalis Seed Oil delivers gamma-linolenic acid, an essential fatty acid studied in dermatology5. Multi-Weight Hyaluronic Acid pairs surface-hydrating and stratum-corneum-penetrating molecular weights6.
- Ye S, Lee S, Kang S, Jun SH, Kang NG. Improvement of Skin Condition Through RXR Alpha-Activating Materials. Biomolecules. 2025;15(2):296. DOI 10.3390/biom15020296. PubMed PMID 40001599.
- Gallelli L. Escin: a review of its anti-edematous, anti-inflammatory, and venotonic properties. Drug Design, Development and Therapy. 2019;13:3425-3437. DOI 10.2147/DDDT.S207720. PubMed PMID 31631970.
- Garre A, Martinez-Masana G, Piquero-Casals J, Granger C. Redefining face contour with a novel anti-aging cosmetic product: an open-label, prospective clinical study. Clinical, Cosmetic and Investigational Dermatology. 2017;10:473-482. PubMed PMID 29180884.
- Dieamant G, Pereda MdelC, Nogueira C, et al. Antiageing Mechanisms of a Standardized Supercritical CO2 Preparation of Black Jack (Bidens pilosa L.) in Human Fibroblasts and Skin Fragments. Evidence-Based Complementary and Alternative Medicine. 2015;2015:280529. DOI 10.1155/2015/280529. PubMed PMID 25883669.
- Fenner J, Silverberg NB. Oral supplements in atopic dermatitis. Clinics in Dermatology. 2018;36(5):653-658. DOI 10.1016/j.clindermatol.2018.05.010. PubMed PMID 30217278.
- Pavicic T, Gauglitz GG, Lersch P, et al. Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. Journal of Drugs in Dermatology. 2011;10(9):990-1000. PubMed PMID 22052267.
How to cite this product page: Opuliss. Cellular Anti-Aging Bioretinol Eye Serum. Opuliss Skin product page. 2026. https://opuliss.com/products/retinol-alternative-eye-serum
The Science
Bidens Pilosa Extract is a botanical studied in cosmetics as a plant-based retinol alternative that activates the RXR pathway retinol uses, supporting the appearance of smoother, firmer skin around the eyes without the typical retinol irritation.
Source: Ye S, et al. Biomolecules, 2025 (PMID 40001599).
INSIDE THE SCIENCE
From precision-fermented actives to biomimetic complexes, discover what makes it Opuliss.
BIDENS PILOSA
A plant-based retinol alternative that helps smooth and renew without retinol irritation.
Source: Ye S, et al. Biomolecules, 2025 (PMID 40001599).
COLLAGEN AMINO ESTER
A collagen-derived amino-acid ester that helps condition the skin.
MARINE BIOFERMENT
A deep-sea marine ferment that soothes and helps comfort sensitive skin.
Source: Le Costaouëc T, et al. Carbohydrate Polymers, 2012 (PMID 24751009).
HOW TO USE
Dispense a rice-grain quantity onto the ring finger and pat gently along the orbital bone from the inner corner outward.
Use morning and evening after cleansing, before moisturiser or SPF.
Allow 30 seconds to absorb before layering serums or sunscreen.
THE TEXTURE
The Opuliss difference
SCIENCE, MADE VISIBLE
Opuliss begins where the research ends. Every active is named, every claim is traceable, and nothing is left to promise alone.
Morning to night
A RITUAL, CONSIDERED
Each formula stands on its own and belongs to the whole. Layered with intention, morning and night, the routine becomes unmistakably yours.
A twenty four hour rhythm
THE SKIN KEEPS TIME
Skin is not the same at midnight as it is at nine in the morning. Across a single day its temperature, its acidity and the moisture it loses to the air each move on a rhythm of their own. Morning and night are not two routines. They are one, kept in time.
Yosipovitch G et al. Journal of Investigative Dermatology, 1998 (PMID 9424081). Sixteen volunteers sampled every two hours across a twenty four hour span.
