CELLULAR ANTI-AGING BIORETINOL DAILY CREAM
A daytime botanical alternative to retinol, built on Bidens Pilosa Extract, which, tested on its own in the lab, gave a small rise in the activity of RXR alpha, a receptor retinol also works through, without activating the receptor linked to retinol irritation. Multi-weight hyaluronic acid and plant butters keep skin hydrated and comfortable for daily morning wear.
Backed by published research · references belowContains fragrance (Parfum). Full ingredients
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Formulated for Acne Prone and Anti-Aging skin.
- Bidens Pilosa Extract, a botanical retinol alternative, combined with andrographolide, improved the look of wrinkles, elasticity and hydration in a human trial without irritation1.
- Sea Buckthorn Fruit Extract supports the appearance of the skin barrier through its flavonoids2.
- Multi-weight Hyaluronic Acid holds hydration at multiple depths for a plumper, more hydrated look3.
Hero mechanism: Bidens Pilosa Extract was studied in a fixed combination for RXR alpha activation and extracellular matrix gene expression in cell models. Full mechanism and citations under Details and references.
A 50 ml / 1.69 fl oz daytime cream built on a five-active stack: Bidens Pilosa Extract (a botanical retinol alternative), Dipalmitoyl Hydroxyproline (a collagen amino acid ester), Alteromonas Ferment Extract (a marine ferment), Rose Myrtle Fruit Extract, and Sea Buckthorn Fruit Extract, with multi-weight Hyaluronic Acid and Murumuru Seed Butter. 99% natural origin, 23% organic origin, vegan eligible.
Bidens Pilosa Extract (Plant-Based Retinol Alternative), Dipalmitoyl Hydroxyproline (Collagen Amino Acid Ester), Alteromonas Ferment Extract (Marine Ferment), Rose Myrtle Fruit Extract, Sea Buckthorn Fruit Extract, Multi-Weight Hydrolyzed Hyaluronic Acid + Sodium Hyaluronate.
Active ingredients:
- Bidens Pilosa Extract, a botanical RXR pathway activator
- Dipalmitoyl Hydroxyproline, a collagen amino acid ester
- Alteromonas Ferment Extract4, a marine ferment
Aloe Barbadensis (Aloe) Leaf Juice, Simmondsia Chinensis (Jojoba) Seed Oil, Glycerin, Pentylene Glycol, Polyglyceryl-6 Stearate, Cetearyl Alcohol, Aqua/Water, Sodium PCA, Dipalmitoyl Hydroxyproline, Astrocaryum Murumuru Seed Butter, Hippophae Rhamnoides (Sea Buckthorn) Fruit Extract, Gossypium Herbaceum Seed Oil, Propanediol, Bidens Pilosa Extract, Dicaprylyl Carbonate, Polyglyceryl-6 Behenate, Parfum/Fragrance, Linum Usitatissimum Seed Oil, Mangifera Indica (Mango) Seed Butter, Caprylic/Capric Triglyceride, Coco-Caprylate, Xanthan Gum, Octyldodecanol, Palmitic Acid, Stearic Acid, Tocopherol, Ascorbyl Palmitate, Potassium Hydroxide, Rhodomyrtus Tomentosa (Rose Myrtle) Fruit Extract, Hydrolyzed Hyaluronic Acid, Sodium Hyaluronate, Sodium Phytate, Alteromonas Ferment Extract, Phenethyl Alcohol, Geraniol, Citronellol, Pelargonium Graveolens Flower Oil, Linalool, Citral
The ingredient list printed on your product’s packaging is always definitive; where it differs from this page, the packaging prevails.
- Apply in the morning to clean skin after toner and serum. Press gently into face and neck.
- Layer with broad-spectrum SPF 30 or higher daily.
- Compatible with your other Opuliss Skin actives, including salicylic acid in an evening routine.
What can I use if I'm allergic to retinol?
This cream contains no retinol. Its lead active is Bidens Pilosa Extract, a botanical that, tested on its own in the lab, gave a small rise in the activity of RXR alpha, a receptor retinol also works through, without activating the receptor linked to retinol irritation. It is from the daisy family, so if you react to ragweed, chamomile or arnica, patch test on the inner forearm for 24 hours before facial use.
Does a plant based retinol alternative actually work?
Ye 2025 showed a fixed combination activated retinoid X receptor alpha and enhanced extracellular matrix gene expression in cell models, with a small clinical cohort reporting improvements in the look of wrinkles, elasticity, and hydration without irritating side effects. The full citation is on this page.
What should I not mix this with?
It is compatible with your other Opuliss Skin actives, including salicylic acid in an evening routine. The one thing to add rather than avoid is sun protection, a broad-spectrum SPF 30 or higher layered over the top daily.
What are the potential side effects of using Bidens pilosa?
It contains Bidens Pilosa Extract, from the Asteraceae daisy plant family. If you know you react to ragweed, chamomile, arnica, chrysanthemum, marigold, echinacea, or yarrow, patch test on the inner forearm for 24 hours before facial use.
99% natural origin, 23% organic origin, vegan eligible. Contains Bidens Pilosa Extract, from the Asteraceae (daisy) plant family. If you know you react to ragweed, chamomile, arnica, chrysanthemum, marigold, echinacea, or yarrow, patch test on the inner forearm for 24 hours before facial use. Contains naturally occurring fragrance allergens (Geraniol, Citronellol, Linalool, Citral).
Bidens Pilosa Extract delivers a botanical retinoid-pathway mechanism. Ye 2025 showed a fixed combination activated retinoid X receptor (RXR) alpha and enhanced extracellular matrix gene expression in cell models, with a small clinical cohort reporting improvements in the look of wrinkles, elasticity, and hydration without irritating side effects1. Sea Buckthorn Fruit Extract supports the appearance of barrier comfort via its flavonoid antioxidants2. Multi-weight Hyaluronic Acid hydrates at multiple stratum corneum depths via molecular size variance3.
- Ye S, Lee S, Kang S, Jun SH, Kang NG. Improvement of Skin Condition Through RXR Alpha-Activating Materials. Biomolecules. 2025;15(2):296. DOI 10.3390/biom15020296. PubMed PMID 40001599.
- Gu Y, Wang X, Liu F, et al. Total flavonoids of sea buckthorn (Hippophae rhamnoides L.) improve MC903-induced atopic dermatitis-like lesions. Journal of Ethnopharmacology. 2022;292:115195. DOI 10.1016/j.jep.2022.115195. PubMed PMID 35306042.
- Ni C, Zhang Z, Wang Y, et al. Hyaluronic acid and HA-modified cationic liposomes for promoting skin penetration and retention. Journal of Controlled Release. 2023;357:432-443. DOI 10.1016/j.jconrel.2023.03.049. PubMed PMID 37004799.
- Garre A, Martinez-Masana G, Piquero-Casals J, Granger C. Redefining face contour with a novel anti-aging cosmetic product: an open-label, prospective clinical study. Clinical, Cosmetic and Investigational Dermatology. 2017;10:473-482. PubMed PMID 29180884.
How to cite this product page: Opuliss. Cellular Anti-Aging Bioretinol Daily Cream. Opuliss Skin product page. 2026. https://opuliss.com/products/retinol-alternative-moisturiser
The Science
Bidens Pilosa Extract is a botanical studied as a plant-based retinol alternative. Tested on its own in the lab, it gave a small rise in the activity of RXR alpha, a receptor retinol also works through, without activating RAR gamma, the receptor linked to retinol irritation.
Source: Ye S, et al. Biomolecules, 2025 (PMID 40001599).
INSIDE THE SCIENCE
From precision-fermented actives to biomimetic complexes, discover what makes it Opuliss.
BIDENS PILOSA
A plant-based retinol alternative. Tested on its own in the lab, it gave a small rise in the activity of RXR alpha, a receptor retinol also works through, without activating the receptor linked to retinol irritation.
Source: Ye S, et al. Biomolecules, 2025 (PMID 40001599).
COLLAGEN AMINO ESTER
A collagen-derived amino-acid ester that helps condition the skin.
Source: European Commission CosIng database, Dipalmitoyl Hydroxyproline, entry 75923.
MARINE BIOFERMENT
A ferment made by Alteromonas bacteria, listed in the EU cosmetic ingredient database as a skin-conditioning ingredient.
Source: European Commission CosIng database, Alteromonas Ferment Extract, entry 54308.
HOW TO USE
Apply to clean skin after your toner and serum.
Press gently into the face and neck until fully absorbed.
Layer a broad-spectrum SPF 30 or higher over the top, every morning.
THE TEXTURE
The Opuliss difference
SCIENCE, MADE VISIBLE
Opuliss begins where the research ends. Every active is named, every claim is traceable, and nothing is left to promise alone.
Morning to night
A RITUAL, CONSIDERED
Each formula stands on its own and belongs to the whole. Layered with intention, morning and night, the routine becomes unmistakably yours.
A twenty four hour rhythm
THE SKIN KEEPS TIME
Skin is not the same at midnight as it is at nine in the morning. Across a single day its temperature, its acidity and the moisture it loses to the air each move on a rhythm of their own. Morning and night are not two routines. They are one, kept in time.
Yosipovitch G et al. Journal of Investigative Dermatology, 1998 (PMID 9424081). Sixteen volunteers sampled every two hours across a twenty four hour span.
