HEXAPEPTIDE FIRMING SERUM
A hexapeptide firming serum for the look of firmer, more elastic skin. Hexapeptide-11 works through the signaling-peptide mechanism class, while a natural ceramide complex and multi-weight hyaluronic acid comfort and plump the barrier for a hydrated, more comfortable finish.
Backed by published research · references belowFormulated for Anti-Aging and Dry Skin.
- Hexapeptide-11, a signal peptide, is studied in cosmetic literature for the appearance of skin firmness1.
- Multi-weight hyaluronic acid, a humectant pairing surface and penetrating molecular weights, helps the skin appear plumper and more hydrated2.
- Natural Ceramide Complex (Glycosphingolipids and Glycolipids), a barrier-conditioning lipid blend that supports the appearance of a comforted, hydrated barrier.
Hero mechanism: Hexapeptide-11, a signal peptide, is documented in cosmetic literature for the signaling peptide mechanism class associated with the appearance of firmness. Full mechanism and citations under Details and references.
A 30 ml / 1.01 fl oz anti-aging face serum built on a five-active composition: Hexapeptide-11 (a signal peptide), Dipalmitoyl Hydroxyproline (a collagen amino acid ester), a natural Ceramide Complex of Glycosphingolipids and Glycolipids, Phytosterols, and Blueberry Seed Oil, with a multi-weight hyaluronic acid blend. 99% natural origin, 20% organic origin, vegan eligible.
Hexapeptide-11 (Signal Peptide), Dipalmitoyl Hydroxyproline (Collagen Amino Acid Ester), Glycosphingolipids + Glycolipids (Natural Ceramide Complex), Phytosterols, Vaccinium Myrtillus (Blueberry) Seed Oil, Multi-Weight Hydrolyzed Hyaluronic Acid + Sodium Hyaluronate.
Active ingredients: Hexapeptide-11 (a signal peptide); Dipalmitoyl Hydroxyproline (a collagen amino acid ester); Glycosphingolipids and Glycolipids (a natural Ceramide Complex, barrier-conditioning lipids).
Aloe Barbadensis (Aloe) Leaf Juice, Glycerin, Simmondsia Chinensis (Jojoba) Seed Oil, Aqua/Water, Pentylene Glycol, Cetearyl Alcohol, Sodium PCA, Isoamyl Laurate, Glyceryl Stearate Citrate, Dipalmitoyl Hydroxyproline, Propanediol, Parfum/Fragrance, Caprylic/Capric Triglyceride, Fragaria Ananassa (Strawberry) Seed Oil, Vaccinium Myrtillus (Blueberry) Seed Oil, Xanthan Gum, Hexapeptide-11, Phytosterols, Ricinus Communis (Castor) Seed Oil, Ascorbyl Palmitate, Hydrolyzed Hyaluronic Acid, Potassium Hydroxide, Sodium Hyaluronate, Sodium Phytate, Tocopherol, Leuconostoc/Radish Root Ferment Filtrate, Ginkgo Biloba Leaf Extract, CI 77491 (Iron Oxides), Citric Acid, Sodium Benzoate, Potassium Sorbate, Glycolipids, Linalool, Geraniol, Citronellol
The ingredient list printed on your product’s packaging is always definitive; where it differs from this page, the packaging prevails.
- Apply two to three drops to clean skin morning and evening, after toner and before moisturiser.
- Press gently into the face and neck.
- Layer with broad-spectrum SPF 30 or higher daily.
99% natural origin, 20% organic origin, vegan eligible. Contains naturally occurring fragrance allergens (Linalool, Geraniol, Citronellol). Patch test on the inner forearm for 24 hours before facial use, and discontinue if irritation occurs.
Hexapeptide-11 is a signal peptide studied in cosmetic literature for the signaling peptide mechanism class associated with the appearance of skin firmness1. Multi-weight hyaluronic acid pairs surface and penetrating molecular weights for a plumper, more hydrated look2, and the natural Ceramide Complex of Glycosphingolipids and Glycolipids is a barrier-conditioning lipid blend.
- Schagen SK. Topical Peptide Treatments with Effective Anti-Aging Results. Cosmetics. 2017;4(2):16. DOI 10.3390/cosmetics4020016.
- Pavicic T, Gauglitz GG, Lersch P, et al. Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. Journal of Drugs in Dermatology. 2011;10(9):990-1000. PubMed PMID 22052267.
How to cite this product page: Opuliss. Hexapeptide Firming Serum. Opuliss Skin product page. 2026. https://opuliss.com/products/peptide-anti-aging-serum
The Science
Hexapeptide-11 is a synthetic signal peptide studied in human dermal fibroblasts, where published research reported support for the skin's proteostasis processes and an improvement in skin elasticity in an in vivo deformation assay.
Source: Sklirou AD, et al. Redox Biology, 2015 (PMID 25974626).
INSIDE THE SCIENCE
From precision-fermented actives to biomimetic complexes, discover what makes it Opuliss.
SIGNAL PEPTIDE
A signal peptide that helps support firmness and a smoother look.
Source: Sklirou AD, et al. Redox Biology, 2015 (PMID 25974626).
COLLAGEN AMINO ESTER
A collagen-derived amino-acid ester that helps condition the skin.
CERAMIDE COMPLEX
Natural ceramides that reinforce the barrier and help lock in moisture.
Source: Andrew PV, et al. The British Journal of Dermatology, 2025 (PMID 40408261).
HOW TO USE
Apply two to three drops to clean skin morning and evening, after toner and before moisturiser.
Press gently into the face and neck.
Layer with broad-spectrum SPF 30 or higher daily.
THE TEXTURE
The Opuliss difference
SCIENCE, MADE VISIBLE
Opuliss begins where the research ends. Every active is named, every claim is traceable, and nothing is left to promise alone.
Morning to night
A RITUAL, CONSIDERED
Each formula stands on its own and belongs to the whole. Layered with intention, morning and night, the routine becomes unmistakably yours.
A twenty four hour rhythm
THE SKIN KEEPS TIME
Skin is not the same at midnight as it is at nine in the morning. Across a single day its temperature, its acidity and the moisture it loses to the air each move on a rhythm of their own. Morning and night are not two routines. They are one, kept in time.
Yosipovitch G et al. Journal of Investigative Dermatology, 1998 (PMID 9424081). Sixteen volunteers sampled every two hours across a twenty four hour span.
